Related Experiment Video
Updated: May 27, 2026

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
Published on: December 11, 2017
Callosal warning syndrome
Ramachandiran Nandhagopal1, Abdullah Al-Asmi, William James Johnston
1Unit of Neurology, Department of Medicine, College of Medicine and Health Sciences, P.O. Box. 35, SQU, Al-Khod, Zip 123, Muscat, Oman. rnandagopal@yahoo.com
Objective:
To report the clinical and imaging findings in a patient with an initial fluctuating disconnection syndrome due to corpus callosal ischemia that ultimately culminated in infarction with persistent symptoms.
Case Report:
A 40-year-old, hypertensive, right-handed man presented with transient, stereotyped symptoms of corpus callosal disconnection (intermanual conflict, apraxia, dysgraphia and construction difficulties in his left hand). Serial magnetic resonance imaging scans demonstrated the ischemic nature of the initial fluctuating symptoms and later showed callosal infarction when the symptoms were persistent. Magnetic resonance angiogram did not reveal significant stenosis or occlusion of the internal carotid or proximal portion of anterior cerebral arteries. Patient received standard treatment for ischemic stroke and at follow-up 1 month later, had mild left hand apraxia, dysgraphia and construction difficulties.
Conclusion:
The case highlights the unusual occurrence of crescendo transient ischemic attacks culminating in infarction in the location of corpus callosum. We have termed this novel stroke syndrome as 'callosal warning syndrome' as the temporal profile was quite indistinguishable from that of relatively well-known stroke warning syndromes in the location of internal capsule and pontine tegmentum.
Related Concept Videos
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Cerebral Edema ll: Pathophysiology
Cerebral Edema l: Introduction
Conditioned Taste Aversion
A notable characteristic of conditioned taste aversion is that it often requires only a single exposure...
Visual Agnosia
Major Somatic Sensory Pathways

