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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Multifocal papillary thyroid carcinoma associated with primary amyloid goiter
Andrés Coca-Pelaz1, Blanca Vivanco-Allende, Cesar Alvarez-Marcos
1Department of Otorhynolaryngology of the Hospital Universitario Central de Asturias, Oviedo, Spain. acocapelaz@yahoo.es
Auris, Nasus, Larynx
|November 15, 2011
Summary
Amyloid goiter, a rare thyroid enlargement, can conceal papillary thyroid carcinoma. Early diagnosis and treatment are crucial for managing this rare association.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Amyloid goiter is a rare thyroid condition caused by amyloid deposition.
- Differentiated carcinomas developing within amyloid goiter are extremely uncommon.
Observation:
- This report details the sixth known case of papillary thyroid carcinoma within an amyloid goiter.
- It is the first reported instance of multifocal papillary carcinoma causing compressive symptoms in this context.
Findings:
- A 45-year-old woman with primary amyloidosis and chronic renal failure presented with a multifocal papillary thyroid carcinoma of the follicular variant within an amyloid goiter.
- Histological examination and Congo red staining confirmed the diagnosis. The patient underwent total thyroidectomy and remains recurrence-free after 2.5 years.
Implications:
- Amyloid goiter can mask differentiated thyroid carcinoma, necessitating awareness of this association.
- Early diagnosis and treatment are vital for improving patient outcomes in such rare cases.
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