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Updated: May 27, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
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Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model.

Ahmet Guven1, Bulent Uysal, Gokhan Gundogdu

  • 1Department of Pediatric Surgery, Gulhane Military Medical Faculty, Etlik, 06018 Ankara, Turkey. drahmetguven@yahoo.com

Journal of Pediatric Surgery
|November 15, 2011
PubMed
Summary

Melatonin (M) effectively reduced the severity of necrotizing enterocolitis (NEC) in a neonatal rat model. This study demonstrates melatonin

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Area of Science:

  • Neonatal research
  • Gastroenterology
  • Pharmacology

Background:

  • Necrotizing enterocolitis (NEC) poses a significant threat to neonates.
  • Investigating therapeutic interventions for NEC is crucial.

Purpose of the Study:

  • To evaluate the efficacy of melatonin (M) in mitigating NEC severity.
  • To assess melatonin's impact on biochemical and histopathological markers of NEC in a neonatal rat model.

Main Methods:

  • Neonatal rats were divided into three groups: NEC, NEC + M, and control.
  • NEC was induced via enteral feeding, cold stress, and hypoxia.
  • Melatonin (10 mg/kg) was administered daily to the NEC + M group for three days.

Main Results:

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Last Updated: May 27, 2026

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Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
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Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

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  • The NEC group exhibited higher mortality and weight loss.
  • Melatonin administration normalized oxidative stress markers (malondialdehyde, protein carbonyl, superoxide dismutase, glutathione peroxidase).
  • Melatonin reduced pro-inflammatory cytokines (TNF-α, IL-1β) and histopathological injury scores.

    • Conclusions:

    • Melatonin significantly ameliorates the severity of necrotizing enterocolitis.
    • Melatonin demonstrates protective effects against NEC-induced oxidative stress and inflammation.