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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Principles of Drug Action01:24

Principles of Drug Action

Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Symbiosis00:58

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

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Updated: May 27, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
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Published on: July 11, 2025

Drugs for malaria: something old, something new, something borrowed.

Charlotte Hobbs, Patrick Duffy

    F1000 Biology Reports
    |November 15, 2011
    PubMed
    Summary

    New malaria treatments are crucial as drug resistance grows. Promising avenues include novel drug discovery, repurposed medicines, and transmission-blocking strategies to combat this devastating disease.

    Area of Science:

    • Tropical medicine
    • Parasitology
    • Drug discovery

    Background:

    • Malaria caused an estimated 800,000 deaths and 225 million cases in 2010.
    • Current first-line treatments (artemisinins) face growing parasite resistance.
    • Urgent need for new antimalarial strategies to combat global malaria burden.

    Purpose of the Study:

    • To explore novel and existing antimalarial drug development avenues.
    • To identify strategies for overcoming artemisinin resistance.
    • To investigate methods for interrupting malaria parasite transmission.

    Main Methods:

    • Review of emerging drug discovery technologies.
    • Evaluation of repurposed and rehabilitated antimalarial compounds.
    • Assessment of resistance-inhibiting and transmission-blocking drug mechanisms.

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    Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
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    Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

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    Last Updated: May 27, 2026

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    Published on: July 11, 2025

    Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
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    Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

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    Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
    08:31

    Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

    Published on: October 11, 2019

    Main Results:

    • New drug discovery technologies offer novel approaches, though clinical application is 10-15 years away.
    • Rehabilitated drugs, resistance inhibitors, and cross-disease treatments show promise.
    • Targeting parasite stages during transmission or liver development may halt spread.

    Conclusions:

    • Multiple innovative strategies are emerging to combat malaria.
    • A combination of new drugs, repurposed therapies, and transmission interruption is key.
    • Addressing drug resistance and transmission is vital for malaria eradication efforts.