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What about the renal function during childhood of children born from dialysed mothers?

Pauline Abou-Jaoude1, Laurence Dubourg, Lucie Bessenay

  • 1Service de Néphrologie et Rhumatologie Pédiatriques, Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, Bron, France.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|November 15, 2011
PubMed

Insights

Children born to mothers on dialysis may face risks to their kidney health. This study found potential signs of renal impairment, emphasizing the need for careful monitoring of these infants.

Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Maternal-Fetal Medicine

Background:

  • Pregnancy during dialysis is increasingly common and poses risks.
  • Infants born to mothers on dialysis may experience developmental issues affecting renal outcome.
  • Potential risks include exposure to toxins, hemodynamic changes, prematurity, and growth retardation.

Purpose of the Study:

  • To investigate the renal outcome in children born to mothers undergoing hemodialysis during pregnancy.
  • To assess potential long-term effects on kidney development and function in this high-risk pediatric population.

Main Methods:

  • Prospective evaluation of 10 children born to 7 mothers on hemodialysis.
  • Renal function assessed via inulin clearance or Schwartz formula (for children <4 years).
  • Analysis included birth weight, gestational age, and markers of kidney damage (albumin-to-creatinine ratio, beta-2-microglobulin).

Main Results:

  • Seven out of ten infants were born preterm (before 36 weeks gestation).
  • Eight out of ten infants had low birth weight (<2500g).
  • While GFR and blood pressure were normal, three children showed elevated urine albumin-to-creatinine ratio and one had increased beta-2-microglobulin, suggesting potential subclinical renal damage.

Conclusions:

  • This pilot study indicates a potential risk of renal impairment in children born to mothers on dialysis.
  • Further research is necessary to fully understand the long-term renal outcomes.
  • Close monitoring of these children is crucial for early detection of kidney issues.
Abstract

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