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Related Experiment Video

Updated: May 27, 2026

Using Magnetometry to Monitor Cellular Incorporation and Subsequent Biodegradation of Chemically Synthetized Iron Oxide Nanoparticles

Using Magnetometry to Monitor Cellular Incorporation and Subsequent Biodegradation of Chemically Synthetized Iron Oxide Nanoparticles

Published on: February 27, 2021

Ferrofluid mediated nanocytometry.

Ayse Rezzan Kose¹, Hur Koser

¹School of Engineering and Applied Science, Yale University, 15 Prospect St., Becton Center, Room 608, New Haven, CT 06520-8267, USA. ayse.kose@yale.edu

|November 15, 2011

Summary

This study introduces a low-cost nanocytometer for label-free microparticle separation using magnetic nanoparticles. The device achieves high efficiency and throughput, making it suitable for cell sorting applications.

Area of Science:

Biotechnology
Nanotechnology
Microfluidics

Background:

Conventional cell sorting methods can be expensive and complex.
Label-free separation techniques are desirable for preserving cell viability.

Purpose of the Study:

To develop a low-cost, flow-through nanocytometer for label-free microparticle and cell separation.
To demonstrate size-based separation mediated by magnetic nanoparticle interactions.

Main Methods:

Utilized a colloidal suspension of non-functionalized magnetic nanoparticles.
Employed magnetically excited ferrofluid particles for angular momentum transfer.
Implemented a flow-through microfluidic device for particle manipulation.

Main Results:

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Achieved rapid sorting and focusing of multiple microparticle species.
Demonstrated up to 99% separation efficiency.
Reported a throughput of 3 × 10(4) particles/s per mm(2).

Conclusions:

The developed nanocytometer offers a simple, inexpensive, and scalable solution for microparticle and cell sorting.
The technology provides competitive performance for cytometer applications, including live cell sorting.