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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
Cortical lesions in radiologically isolated syndrome
A Giorgio1, M L Stromillo, F Rossi
1Department of Neurological and Behavioral Sciences, University of Siena, Siena, Italy.
Neurology
|November 15, 2011
Summary
Cortical lesions (CLs) were found in 40% of individuals with radiologically isolated syndrome (RIS), indicating a higher risk for developing multiple sclerosis (MS). These CLs were linked to white matter lesion volume and MS progression markers.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Radiologically isolated syndrome (RIS) presents with MRI findings suggestive of multiple sclerosis (MS) but lacks clinical symptoms.
- Cortical lesions (CLs) are increasingly recognized as important markers in MS pathogenesis.
Purpose of the Study:
- To determine the prevalence and characteristics of cortical lesions (CLs) in subjects diagnosed with radiologically isolated syndrome (RIS).
Main Methods:
- MRI scans, including double inversion recovery sequences, were performed on 15 subjects with RIS.
- Assessment included identification of CLs, measurement of T2-hyperintense white matter (WM) lesion volume (LV), and brain/cortical volumes.
Main Results:
- Cortical lesions (CLs) were detected in 6 out of 15 (40%) RIS subjects, primarily in the frontotemporal lobes.
- CLs were associated with the presence of immunoglobulin G oligoclonal bands, cervical cord lesions, and dissemination in time on MRI.
- Subjects with CLs had significantly higher white matter lesion volume (WM LV) and showed a correlation between CLs and WM LV.
Conclusions:
- Cortical lesions (CLs) are present in a significant proportion of individuals with radiologically isolated syndrome (RIS).
- The presence and localization of CLs in RIS are associated with markers predictive of conversion to multiple sclerosis (MS).
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