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Published on: May 2, 2018
Peptidoglycan recognition proteins: modulators of the microbiome and inflammation
Julien Royet1, Dipika Gupta, Roman Dziarski
1Institut de Biologie du Développement de Marseille-Luminy, UMR6216 CNRS et Aix-Marseille Universites, Parc Scientifique de Luminy, Marseille, France. julien.royet@univmed.fr
Abstract:
All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota-host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules - the peptidoglycan recognition proteins - has evolved a fascinating variety of mechanisms to control host interactions with mutualistic, commensal and parasitic microorganisms to benefit both invertebrate and vertebrate hosts.
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