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Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

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Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

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Microfabricated particulate drug-delivery systems.

Jing Pan¹, Sui Yung Chan, Won Gu Lee

¹Department of Pharmacy, National University of Singapore, Singapore.

Biotechnology Journal

|November 15, 2011

Summary

Micro- and nanoparticles are key in drug-delivery systems (DDSs). Microfabrication offers better control over particle size and shape, overcoming limitations in current DDS development.

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Area of Science:

Formulation Science
Biomaterials Engineering
Nanotechnology

Background:

Particulate drug-delivery systems (DDSs) are crucial in formulation science.
Current challenges include controlling the homogeneity of micro-/nanoparticle size and shape.
While some DDSs utilize scaffolds, many are scaffold-free or encapsulated within biomaterials.

Purpose of the Study:

To review advancements in micro-/nanoparticulate DDSs.
To highlight microfabrication techniques for DDS development.
To discuss overcoming limitations in conventional particle fabrication.

Main Methods:

Review of recent literature on microfabrication techniques for DDS.
Analysis of approaches for scaffold-free micro-/nanoparticle generation.
Discussion of architectural control in particulate DDS.

Main Results:

Microfabrication enables highly controllable architectures for micro-/nanoparticles.
These techniques offer improved homogeneity in particle size and shape.
Scaffold-free DDS fabrication is advancing rapidly.

Conclusions:

Microfabrication presents a promising approach for advanced DDS.
This technology can overcome drawbacks of conventional particle fabrication methods.
Enhanced control over DDS architecture is achievable, improving drug delivery efficacy.