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Long-lasting elevation of alanine in brain produced by the antidepressant phenelzine
J T Wong1, G B Baker, R T Coutts
1Department of Psychiatry, University of Alberta, Edmonton, Canada.
Brain Research Bulletin
|July 1, 1990
Abstract:
Time- and dose-response studies were conducted to determine the effects of the antidepressant and antipanic drug phenelzine (a monoamine oxidase inhibitor) on whole brain levels of the aliphatic amino acid alanine. At a dose of phenelzine of 15 mg/kg IP, there was a significant increase in brain levels of alanine up to 16 hr after drug administration. Dose studies at 4 hr indicated that the alanine elevation after phenelzine was a dose-dependent effect.