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Related Experiment Video

Updated: May 27, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

The behavioral activation system and mania.

Sheri L Johnson1, Michael D Edge, M Kathleen Holmes

  • 1Department of Psychology, University of California, Berkeley, Berkeley, California 94720, USA. sljohnson@berkeley.edu

Annual Review of Clinical Psychology
|November 15, 2011
PubMed
Summary
This summary is machine-generated.

Mania may be linked to an overactive behavioral activation system (BAS), which drives reward-seeking behavior. This review explores evidence supporting the BAS model in bipolar disorder, suggesting specific sensitivity aspects for future research and treatment.

Related Experiment Videos

Last Updated: May 27, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

  • Psychiatry
  • Neuroscience
  • Behavioral Science

Background:

  • Theorists have long proposed a link between mania and heightened sensitivity of the behavioral activation system (BAS).
  • A growing body of empirical research supports this theoretical model.
  • Previous research has primarily focused on general BAS sensitivity in mania.

Purpose of the Study:

  • To review the empirical literature supporting the behavioral activation system (BAS) model of mania.
  • To explore specific facets of BAS sensitivity relevant to bipolar disorder.
  • To identify future research directions and treatment implications for the BAS model in bipolar disorder.

Main Methods:

  • Review of cross-sectional studies examining BAS sensitivity and bipolar disorder.
  • Analysis of prospective studies investigating the relationship between BAS and manic symptoms.
  • Synthesis of existing literature on effort expenditure, reward sensitivity, and goal pursuit in bipolar disorder.

Main Results:

  • Evidence suggests bipolar disorder is associated with increased willingness to exert effort for rewards.
  • Findings indicate heightened energy and goal pursuit following initial reward experiences in bipolar disorder.
  • The reviewed literature supports a nuanced view of BAS sensitivity in mania.

Conclusions:

  • The behavioral activation system (BAS) model provides a valuable framework for understanding mania.
  • Further research should focus on specific aspects of BAS sensitivity, such as effort-based decision-making and reward responsiveness.
  • Understanding these specific mechanisms may lead to more targeted and effective treatments for bipolar disorder.