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Cognitive psychology emerged as a significant field in the mid-20th century. It focused on understanding humans' internal mental processes. This approach emphasizes how people perceive, remember, think, and solve problems—elements critical to human cognition.
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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

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Published on: February 14, 2014

Changes in cognition.

Marilyn S Albert1

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. malbert9@jhmi.edu

Neurobiology of Aging
|November 15, 2011
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) initially impairs episodic memory, affecting learning and new information retention. This memory decline predicts progression to dementia, even in cognitively normal individuals.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Alzheimer's disease (AD) is characterized by progressive cognitive decline.
  • Episodic memory impairment, the ability to learn and retain new information, is an early hallmark of AD.
  • This memory decline is observed in mild cognitive impairment (MCI) and predicts progression to dementia.

Purpose of the Study:

  • To investigate the role of episodic memory impairment in Alzheimer's disease progression.
  • To explore the association between episodic memory performance and AD biomarkers.
  • To examine the relationship between medial temporal lobe structure and memory function in MCI.

Main Methods:

  • Cognitive testing focusing on episodic memory.
  • Assessment of Alzheimer's disease biomarkers.
  • Magnetic resonance imaging (MRI) to measure medial temporal lobe structures.

Main Results:

  • Episodic memory impairment is evident in mild cognitive impairment (MCI) and predicts progression to dementia.
  • Poorer episodic memory performance is observed in cognitively normal individuals likely to progress to MCI.
  • Medial temporal lobe atrophy correlates with memory deficits in MCI patients.
  • Amyloid accumulation shows potential association with memory performance in cognitively normal individuals.

Conclusions:

  • Episodic memory deficits are a key early indicator of Alzheimer's disease.
  • Episodic memory testing can aid in predicting AD progression.
  • Medial temporal lobe integrity and amyloid burden are crucial factors in AD-related memory decline.