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Related Experiment Video

Updated: May 27, 2026

Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles
09:55

Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles

Published on: August 12, 2021

Cutting-hedge research into bacterial invasion.

Douglas A Kuntz1, David R Rose

  • 1Ontario Cancer Institute, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

Structure (London, England : 1993)
|November 15, 2011
PubMed
Summary

Pathogenic bacteria use glycoside hydrolases to break down host cell defenses. A study reveals how bacterial enzymes with multiple hydrolase modules expand their target range, aiding bacterial invasion.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Structural Biology

Background:

  • Pathogenic bacteria employ glycoside hydrolases (GHs) to degrade host cell surface glycans, facilitating infection.
  • Understanding the enzymatic mechanisms of bacterial pathogenesis is crucial for developing targeted therapies.

Discussion:

  • Pluvinage et al. investigate a bacterial polypeptide containing multiple GH modules.
  • This multi-modular enzyme exhibits a broader substrate specificity than single-module enzymes.
  • The findings shed light on how bacteria adapt their enzymatic machinery to overcome host defenses.

Key Insights:

  • Bacterial GHs are key virulence factors that target host glycans.
  • Polypeptides with multiple hydrolase modules offer enhanced substrate specificity.

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Use of the Soft-agar Overlay Technique to Screen for Bacterially Produced Inhibitory Compounds
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Last Updated: May 27, 2026

Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles
09:55

Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles

Published on: August 12, 2021

Invasion of Human Cells by a Bacterial Pathogen
07:15

Invasion of Human Cells by a Bacterial Pathogen

Published on: March 21, 2011

Use of the Soft-agar Overlay Technique to Screen for Bacterially Produced Inhibitory Compounds
06:38

Use of the Soft-agar Overlay Technique to Screen for Bacterially Produced Inhibitory Compounds

Published on: January 14, 2017

  • This broadens the enzymatic repertoire of pathogenic bacteria.

    • Outlook:

    • Further structural and functional studies of multi-modular GHs could reveal novel therapeutic targets.
    • Understanding GH substrate specificity is vital for combating bacterial infections.