Related Experiment Video
Updated: May 27, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
[Systemic autoimmune diseases and depressive disorders].
Sylvia Arias1, Victoria Fonsalía, Nicolás Asteggiante
1Policlínica de Enfermedades Autoinmunes Sistémicas, Hospital Maciel, Montevideo, Uruguay. sylviaarias@montevideo.com.uy
Depression is highly prevalent in patients with systemic autoimmune diseases (SAD), affecting 69% of individuals. This mental health condition frequently co-occurs with pain, fatigue, and sleep disturbances in SAD patients.
Area of Science:
- Rheumatology
- Psychiatry
- Immunology
Context:
- Systemic autoimmune diseases (SAD) are often accompanied by significant psychological distress.
- Depression is a common comorbidity with medical conditions, impacting patient prognosis.
Purpose:
- To investigate the prevalence of depression in patients diagnosed with SAD.
- To assess the frequency of pain, fatigue, and sleep disorders in this population.
- To examine the relationship between depression and these symptoms in SAD patients.
Summary:
- A prospective study of 88 patients with autoimmune diseases (AID) utilized the CES-D, FSS, and Pittsburgh Sleep Quality Index.
- Results indicated a 69% prevalence of depression among AID patients.
- Depression was significantly associated with increased pain (97%), sleep disorders (95%), and fatigue (80%).
Impact:
- Highlights depression as the most frequent comorbidity in SAD.
- Underscores the strong link between depression and debilitating symptoms like pain, fatigue, and sleep issues in autoimmune conditions.
- Emphasizes the need for integrated mental health screening and treatment in rheumatology care.
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Depressive Disorders: MDD and Dysthymia
Depression: Overview
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
