Related Experiment Video
Updated: May 27, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
Low-dose doxycycline plus additional therapies may lower systemic inflammation in postmenopausal women with
1New York University, College of Dentistry, New York, NY 10010, USA. wb36@nyu.edu
Article Title And Bibliographic Information:
The effect of subantimicrobial-dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial. Payne JB, Golub LM, Stoner JA, Lee H-M, Reinhardt RA, Sorsa T, Slepian MJ. J Am Dent Assoc 2011;142;262-73.
Reviewer:
Walter A. Bretz, DDS, PhD.
Purpose/Question:
To determine whether long-term subantimicrobial-dose-doxycycline (SDD) periodontal therapy could reduce serum biomarkers of systemic inflammation and improve lipid profiles in postmenopausal women who have systemic osteopenia and chronic periodontitis.
Source Of Funding:
NIH/NIDCR grant R01DE012872.
Type Of Study/Design:
Randomized controlled trial.
Level Of Evidence:
Level 2: Limited-quality, patient-oriented evidence.
Strength Of Recommendation Grade:
Not applicable.
Related Concept Videos
The Oral Microbiota
Atherosclerosis III: Management
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Endocarditis III: Medical Management
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Acne Infection
