Related Experiment Video

Updated: May 27, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Derepressing nuclear receptors for metabolic adaptation

Alan R Saltiel1

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. saltiel@lsi.umich.edu

Cell
|November 15, 2011
PubMed

Insights

Nuclear receptor corepressor NCoR (Nuclear Receptor Corepressor) is crucial for lipid homeostasis in fat and muscle. Its deletion reveals coordinated control of nuclear receptors regulating fat metabolism.

Area of Science:

  • Molecular Biology
  • Metabolic Research
  • Gene Regulation

Background:

  • Nuclear receptor corepressor NCoR (Nuclear Receptor Corepressor) interacts with various transcription factors.
  • NCoR plays a role in regulating the activity of the PPAR family of nuclear receptors.

Discussion:

  • Specific deletion of NCoR in adipose and muscle tissues was performed by Li et al. and Yamamoto et al.
  • This genetic manipulation allowed for the investigation of NCoR's function in these specific tissues.

Key Insights:

  • NCoR is essential for maintaining lipid homeostasis.
  • NCoR regulates lipid metabolism through the coordinated action of multiple nuclear receptors.
  • The study highlights tissue-specific functions of NCoR in metabolic regulation.

Outlook:

  • Further research can explore therapeutic strategies targeting NCoR for metabolic disorders.
  • Investigating the precise molecular mechanisms of NCoR's coordinated control of nuclear receptors is warranted.
  • Understanding NCoR's role in other tissues may reveal broader implications for metabolic health.

More Related Videos

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells07:22

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...