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Related Concept Videos

Biosynthesis of Lipids01:29

Biosynthesis of Lipids

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Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
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Lipid Catabolism01:25

Lipid Catabolism

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Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
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Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
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Lipid Absorption01:24

Lipid Absorption

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Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
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Lipid Digestion01:06

Lipid Digestion

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Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
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Lipids as Anchors01:32

Lipids as Anchors

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In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
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Related Experiment Video

Updated: Dec 12, 2025

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
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New driver for lipid synthesis.

Sander M Houten1, Carmen A Argmann

  • 1Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. s.m.houten@amc.uva.nl

Cell
|November 15, 2011
PubMed
Summary

Cholesterol

Area of Science:

  • Biochemistry
  • Cell Biology
  • Metabolic Regulation

Background:

  • Sterol regulatory element-binding protein (SREBP) activation is classically regulated by cholesterol via a feedback loop.
  • Cellular lipid synthesis and methylation pathways are fundamental to cell function.

Discussion:

  • Walker et al. (2011) identified a novel regulatory input for SREBP activity.
  • This new pathway involves phosphatidylcholine (PC) and cellular methylation capacity, operating independently of the classic cholesterol feedback loop.
  • The study highlights the intricate crosstalk between lipid metabolism and methylation processes.

Key Insights:

  • Discovery of an independent regulatory loop for SREBP activation.
  • Phosphatidylcholine (PC) and methylation capacity directly influence SREBP activity.

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Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes
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  • Establishes a molecular link connecting lipid synthesis and cellular methylation.

    • Outlook:

    • Further investigation into the precise mechanisms of PC and methylation in SREBP regulation.
    • Exploring the therapeutic potential of targeting this newly identified pathway for metabolic disorders.
    • Understanding the broader implications for cellular homeostasis and disease pathogenesis.