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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
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Published on: May 24, 2021

Etiological diagnosis of left ventricular dysfunction: computed tomography compared with coronary angiography and

Jordi Estornell-Erill1, Begoña Igual-Muñoz, Jose Vicente Monmeneu-Menadas

  • 1Unidad de Imagen Cardiaca, ERESA, Valencia, España.

Revista Espanola De Cardiologia (English Ed.)
|November 15, 2011
PubMed

Insights

Multidetector computed tomography coronary angiography accurately diagnoses left ventricular dysfunction. Combining this with myocardial tissue assessment offers comprehensive diagnostic information, comparable to invasive methods.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Left ventricular dysfunction (LVD) of uncertain etiology requires accurate diagnosis of its coronary cause.
  • Multidetector computed tomography (MDCT) is a non-invasive imaging modality with potential for diagnosing coronary artery disease (CAD).

Purpose of the Study:

  • To assess the diagnostic capability of MDCT in identifying the coronary etiology of LVD.
  • To compare MDCT performance against invasive coronary angiography (ICA) and cardiac magnetic resonance (CMR).

Main Methods:

  • Forty patients with LVD of unknown cause underwent ICA and contrast-enhanced CMR.
  • All patients were evaluated using MDCT, including coronary calcium scoring, non-invasive coronary angiography, and myocardial tissue characterization.

Main Results:

  • MDCT coronary angiography demonstrated 100% sensitivity and 96% specificity for detecting coronary stenoses.
  • MDCT myocardial tissue assessment showed 57% sensitivity and 100% specificity for necrosis on contrast acquisition, and 84% sensitivity and 96% specificity on late acquisition.
  • Combined MDCT coronary angiography and tissue assessment achieved 92% sensitivity and 100% specificity for diagnosing coronary-related LVD.

Conclusions:

  • MDCT coronary angiography is highly accurate for diagnosing the coronary origin of LVD.
  • A combined MDCT approach (coronary angiography and myocardial tissue study) provides diagnostic information equivalent to invasive methods (ICA and CMR).
Abstract

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