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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
Published on: March 14, 2013
Recent and potential developments of biofluid analyses in metabolomics
Aihua Zhang1, Hui Sun, Ping Wang
1National TCM Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Ministry of Education, Heping Road 24, Harbin 150040, China
Journal of Proteomics
|November 15, 2011
Summary
Metabolomics, the study of metabolites, analyzes key molecules in body fluids for disease diagnosis. This approach offers a holistic view, potentially surpassing traditional methods with novel biomarker discovery for improved public health.
Area of Science:
- Systems biology
- Metabolomics
- Biomarker discovery
Background:
- Metabolomics globally assesses endogenous small-molecule metabolites in biological systems.
- Analysis of metabolites in body fluids is crucial for monitoring organism health and diagnosing diseases.
- Metabolomic profiling of biological samples like plasma, serum, and urine is widely utilized.
Purpose of the Study:
- To highlight the application of metabolomics in analyzing biological fluids for disease diagnostics.
- To emphasize the advantages of a holistic approach to metabolism in diagnostics.
- To discuss the potential of metabolomics in advancing biofluid analysis and public health.
Main Methods:
- Global assessment and validation of endogenous small-molecule metabolites.
- Metabolic profiling of various biological samples including plasma, serum, urine, and tissue homogenates.
- Characterization of biological fluids using advanced metabolomic applications.
Main Results:
- Metabolomics provides a comprehensive assessment of metabolites in biological systems.
- Application of metabolomics to biological fluids enables disease diagnostics.
- Metabolomic approaches offer potential advantages over classical diagnostic methods through biomarker discovery.
Conclusions:
- Metabolomics is a key component of systems biology, offering insights into biological systems.
- The analysis of metabolites in body fluids is a vital diagnostic tool.
- Metabolomics holds significant promise for advancing biofluid analyses and improving long-term public health outcomes.
