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Related Experiment Video

Updated: May 27, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Thalassaemia in pregnancy.

Tak Yeung Leung¹, Terence T Lao

¹Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China. tyleung@cuhk.edu.hk

Best Practice & Research. Clinical Obstetrics & Gynaecology

|November 15, 2011

Summary

Thalassaemia, a common genetic disorder, can be diagnosed prenatally using simple screening and advanced genetic tests. Pregnant women with thalassaemia require careful monitoring and management to prevent complications for both mother and child.

Related Experiment Videos

Last Updated: May 27, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Area of Science:

Genetics
Obstetrics
Hematology

Background:

Thalassaemia is the most prevalent monogenetic disorder globally.
Prenatal diagnosis offers effective and timely detection of thalassaemia.
Pregnant women with thalassaemia face significant maternal health risks.

Purpose of the Study:

To review current antenatal screening and diagnostic methods for thalassaemia.
To outline essential management strategies for pregnant women with thalassaemia.
To highlight postpartum care considerations for mothers and newborns affected by thalassaemia.

Main Methods:

Review of antenatal screening techniques, including ultrasound and fetal nucleic acid analysis.
Discussion of pre-implantation genetic diagnosis options.
Standardized management protocols for pregnancy in women with thalassaemia major and intermedia.

Main Results:

Accurate genetic prenatal diagnosis is achievable early in gestation.
Less invasive diagnostic methods are available, including ultrasound and maternal plasma analysis.
Maternal complications associated with thalassaemia include cardiac, infectious, thrombotic, endocrine, and bone issues.

Conclusions:

Close maternal and fetal monitoring is crucial throughout pregnancy.
Interventions like blood transfusions and thromboembolism prophylaxis may be necessary.
Postpartum care involves resuming treatments and providing essential counseling on infant feeding and family planning.