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Updated: May 27, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

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Published on: August 16, 2018

R-Isovaline: a subtype-specific agonist at GABA(B)-receptors?

J E Cooke1, D A Mathers, E Puil

  • 1Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

Neuroscience
|November 15, 2011
PubMed
Summary

R-isovaline, an analgesic amino acid, activates metabotropic GABA(B) receptors in thalamic neurons by increasing potassium (K+) conductance. This activation is G protein-mediated and distinct from baclofen

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