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Related Experiment Video

Updated: May 27, 2026

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques
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Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Published on: September 25, 2018

Experimental SSM-CVB3 infection in macaques.

Tiesuo Han1, Wenqi He, Deguang Song

  • 1College of Animal Science and Veterinary Medicine, Jilin University, Changchun, China. hts-820228@163.com

Experimental and Molecular Pathology
|November 15, 2011
PubMed
Summary

This study shows that the SSM-CVB3 strain causes severe hepatic and renal damage in macaques, in addition to cardiac issues. This macaque model is suitable for studying coxsackievirus B3 (CVB3)-induced organ damage.

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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

Area of Science:

  • Virology
  • Pathology
  • Primate Models

Background:

  • Coxsackievirus B3 (CVB3) is a significant human pathogen.
  • Understanding CVB3 pathogenicity is crucial for developing effective treatments.
  • The pathogenicity of the SSM-CVB3 strain in non-human primates remains largely uncharacterized.

Purpose of the Study:

  • To evaluate the pathogenicity of the SSM-CVB3 strain in a macaque model.
  • To assess the clinical, hematological, biochemical, and histopathological effects of SSM-CVB3 infection.

Main Methods:

  • Macaques were infected with SSM-CVB3.
  • Clinical signs, viral and neutralization titers, hematological and biochemical parameters were monitored.
  • Histopathological analysis and mRNA expression of viral components, CAR, and DAF were performed.

Main Results:

  • SSM-CVB3 infection induced severe clinical symptoms including diarrhea, fever, and organ damage (cardiac, hepatic, renal).
  • Elevated viral titers and specific antibody responses were observed.
  • Significant alterations in hematological parameters and elevated cardiac/hepatic enzymes indicated tissue damage.

Conclusions:

  • This study provides the first report of experimental SSM-CVB3 infection in macaques, demonstrating significant hepatic and renal pathology.
  • The developed macaque model is suitable for investigating CVB3-induced cardiac, hepatic, and renal diseases.
  • Findings highlight the potential of SSM-CVB3 as a model pathogen for studying viral organ damage.