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Hematological malignancy associated with polymyositis and dermatomyositis.
I Marie1, L Guillevin, J-F Menard
1Department of Internal medicine, CHU Rouen, Rouen, France. isabelle.marie@chu-rouen.fr
Autoimmunity Reviews
|November 15, 2011
Summary
This study found polymyositis/dermatomyositis (PM/DM) patients have a higher risk of hematological malignancies, particularly lymphoma. Older age and dermatomyositis (DM) were predictive factors, while anti-Jo1 antibodies indicated lower risk.
Area of Science:
- Rheumatology and Hematology
- Autoimmune Diseases and Malignancies
Background:
- Polymyositis/dermatomyositis (PM/DM) are inflammatory myopathies with potential systemic associations.
- The link between PM/DM and hematological malignancies requires further characterization to identify risk factors and clinical implications.
Purpose of the Study:
- To assess the characteristics of hematological malignancies in patients with polymyositis/dermatomyositis (PM/DM).
- To determine predictive variables for hematological malignancies in PM/DM patients.
Main Methods:
- Retrospective review of medical records for 32 patients diagnosed with PM/DM and associated hematological malignancies.
- Analysis of malignancy types, timing of diagnosis relative to PM/DM, and clinical features.
Main Results:
- Hematological malignancies were identified concurrently (18.8%), during PM/DM (31.2%), or preceded PM/DM (50%).
- B-cell lymphoma was the most common malignancy (n=20).
- Patients with hematological malignancies were older, more frequently had dermatomyositis (DM), and less commonly exhibited joint involvement, interstitial lung disease, or anti-Jo1 antibodies.
Conclusions:
- The association between PM/DM and hematological malignancies, especially lymphoma, is significant and should not be overlooked.
- Older age and DM are potential indicators for hematological malignancy in PM/DM patients.
- The absence of anti-Jo1 antibodies may suggest an increased risk for hematological malignancy.
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