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The level of arabinitol in autistic children after probiotic therapy

Joanna Kałużna-Czaplińska1, Sylwia Błaszczyk

  • 1Institute of General and Ecological Chemistry, Department of Chemistry, Technical University of Lodz, Lodz, Poland. jkaluzna@p.lodz.pl

Nutrition (Burbank, Los Angeles County, Calif.)
|November 15, 2011
PubMed

Insights

Probiotic treatment significantly reduced D-arabinitol (DA) and the DA/L-arabinitol (DA/LA) ratio in autistic children

Area of Science:

  • Biochemistry
  • Pediatrics
  • Microbiology

Background:

  • Elevated D-arabinitol (DA) and DA/L-arabinitol (DA/LA) ratios in urine are observed in children with autism.
  • Investigating biomarkers for autism spectrum disorder (ASD) is crucial for understanding its pathophysiology.

Purpose of the Study:

  • To investigate D-arabinitol (DA) and DA/L-arabinitol (DA/LA) levels in children with autism.
  • To assess the impact of probiotic therapy on DA and DA/LA ratios in autistic children.

Main Methods:

  • Urine samples from autistic children were analyzed before and after probiotic treatment.
  • Capillary gas chromatography/mass spectrometry was used to quantify DA, L-arabinitol (LA), and the DA/LA ratio.

Main Results:

  • Autistic children exhibited significantly higher urinary DA levels compared to controls.
  • Probiotic supplementation led to a significant reduction in both DA and the DA/LA ratio.
  • Improvements in concentration and ability to follow instructions were observed post-probiotic treatment.

Conclusions:

  • Probiotic intervention appears beneficial for reducing DA and DA/LA ratios in children with autism.
  • This suggests a potential role for probiotics in managing certain biochemical markers associated with autism.
Abstract

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