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Published on: May 10, 2024
Treatment adherence in pediatric eosinophilic gastrointestinal disorders
Kevin A Hommel1, James P Franciosi, Elizabeth A Hente
1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA. kevin.hommel@cchmc.org
Insights
Treatment adherence in pediatric eosinophilic gastrointestinal disorders (EGID) is complex. About 30% of children with EGID show medication nonadherence, highlighting varied adherence across treatments.
Area of Science:
- Pediatric Gastroenterology
- Immunology
- Allergy
Background:
- Eosinophilic gastrointestinal disorders (EGID) encompass conditions like eosinophilic esophagitis and gastroenteritis.
- Effective management of EGID relies heavily on consistent treatment adherence.
- Understanding adherence patterns is crucial for optimizing patient outcomes.
Purpose of the Study:
- To investigate treatment adherence rates in children diagnosed with EGID.
- To identify factors contributing to nonadherence in this pediatric population.
Main Methods:
- A multimethod, multi-informant approach was used, involving parent reports and electronic monitoring.
- Participants included children aged 2.5-18 years with EGID and their caregivers.
- Nonadherence was defined as a cut point of 90% adherence.
Main Results:
- Medication nonadherence prevalence was found to be 30%.
- Parent reports indicated 91% adherence, while electronic monitors showed 100% adherence.
- Tube-feeding adherence was high at 99% ± 3%, with 33% nonadherence to food allergen avoidance.
Conclusions:
- A significant subset of pediatric EGID patients exhibit nonadherence to treatments.
- Treatment adherence in EGID is multifaceted, with variations observed across different therapeutic interventions.
- Further research is needed to address the complexities of adherence in EGID management.
Objective:
Examine treatment adherence rates in pediatric eosinophilic gastrointestinal disorders (EGID).
Methods:
Participants were children aged 2.5-18 years with eosinophilic esophagitis or eosinophilic gastroenteritis (EGE) and their caregivers. A multimethod, multi-informant assessment including parent report and electronic monitoring was utilized, with a 90% cut point for nonadherence.
Results:
Medication nonadherence prevalence was 30%. Adherence frequency was 91% ± 14% (0-100%) per parent report and 100% ± 69% (0-194%) per electronic monitors. Tube-feeding adherence was 99% ± 3%. Food allergen exposures were less than 1 per 2 weeks, with 33% nonadherence prevalence. Patients with EGE and toddlers with both conditions demonstrated poorer medication adherence (p's < .05). Caregivers reported higher number of missed medication doses than food exposures (p < .05).
Conclusions:
The prevalence and range of nonadherence demonstrates that subsets of these patients are nonadherent. Adherence to treatment in EGID is complex and multifaceted, with nonadherence varying across treatments.
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