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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Working Memory01:24

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this information.

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Related Experiment Video

Updated: May 27, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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CNTRICS imaging biomarkers selection: Working memory.

Deanna M Barch1, Holly Moore, Derek E Nee

  • 1Department of Psychology, Washington University, St Louis, MO 63130, USA. dbarch@artsci.wustl.edu

Schizophrenia Bulletin
|November 15, 2011
PubMed
Summary
This summary is machine-generated.

The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) consortium identified key working memory tasks for schizophrenia clinical trials. These include goal maintenance and interference control measures for improved cognitive assessment.

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Area of Science:

  • Cognitive Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) consortium aims to standardize cognitive measures for schizophrenia research.
  • Working memory (WM) is a critical cognitive domain affected in schizophrenia, necessitating reliable assessment tools.

Framework:

  • CNTRICS identified core working memory constructs: goal maintenance and interference control.
  • Tasks were nominated and evaluated based on their suitability for clinical trial application.

Implementation:

  • For goal maintenance, the AX Continuous Performance Test/Dot Pattern Expectancy (DPX) and the Switching Stroop task were recommended.
  • For interference control, the Suppress Task and the Sternberg Item Recognition Paradigm were selected.
  • A change detection task measuring delay activity in posterior parietal and occipital cortex was proposed for assessing WM capacity.

Implications:

  • These selected tasks and biomarkers are intended for translation and further development in schizophrenia clinical trials.
  • Standardized cognitive measures will enhance the ability to detect treatment effects on cognition.
  • This work facilitates the development of more effective interventions for cognitive deficits in schizophrenia.