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Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Eukaryotic Transcription Activators02:42

Eukaryotic Transcription Activators

Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...

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Related Experiment Video

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Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences
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AnimalTFDB: a comprehensive animal transcription factor database.

Hong-Mei Zhang1, Hu Chen, Wei Liu

  • 1Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Systems Biology, College of Life Science, Huazhong University of Science and Technology Wenhua College, Wuhan 430074, China.

Nucleic Acids Research
|November 15, 2011
PubMed
Summary

This study presents AnimalTFDB, the most comprehensive animal transcription factor (TF) database, detailing 72 TF families across 50 species. It offers extensive annotations and resources for understanding gene regulation.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Transcription factors (TFs) regulate gene expression by binding DNA.
  • Transcription cofactors and chromatin remodelers are also vital for gene regulation.
  • Comprehensive identification and annotation of TFs are crucial for understanding transcriptional regulation.

Purpose of the Study:

  • To create the most complete list of animal TF families.
  • To systematically characterize TFs in 50 animal species.
  • To build a comprehensive animal TF database (AnimalTFDB) with detailed annotations.

Main Methods:

  • Manual literature review to collect and curate TF families.
  • Systematic characterization of TFs across 50 animal species.
  • Database construction with detailed annotations for TFs, cofactors, and remodelers.

Main Results:

  • Curated 72 animal TF families, the most complete list to date.
  • Systematically characterized TFs in 50 animal species.
  • Developed AnimalTFDB, a comprehensive database with extensive annotations (gene structure, functional domains, pathways, interactions, etc.).

Conclusions:

  • AnimalTFDB provides a valuable, user-friendly resource for researchers.
  • The database facilitates deeper understanding of TF functions and transcriptional regulation in animals.
  • Freely available at http://www.bioguo.org/AnimalTFDB/.