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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

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Related Experiment Video

Updated: May 27, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Platelet function testing in practice: a case study.

Ehtisham Mahmud1, Lawrence Ang

  • 1University of California, San Diego Medical Center, San Diego, CA, USA.

Reviews in Cardiovascular Medicine
|November 15, 2011
PubMed
Summary
This summary is machine-generated.

Dual antiplatelet therapy reduces ischemic events after stenting, but residual risk remains. Point-of-care testing can identify patients with high platelet reactivity, a factor in stent thrombosis.

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Last Updated: May 27, 2026

Microfluidics in Assessing Platelet Function
06:47

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Published on: November 8, 2024

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

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Published on: May 2, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Hematology

Background:

  • Dual antiplatelet therapy (DAPT) with aspirin and a thienopyridine is standard after percutaneous coronary intervention (PCI) to reduce ischemic events.
  • Despite DAPT, a residual risk of ischemic events persists, partly due to enhanced platelet reactivity.
  • Variability in patient response to thienopyridines like clopidogrel is influenced by genetic, pharmacologic, and clinical factors.

Observation:

  • Point-of-care platelet function testing allows for assessment of on-treatment platelet reactivity.
  • These tests can identify patients who are poor responders to thienopyridine therapy.
  • Two cases of stent thrombosis were investigated using the VerifyNow P2Y12 Assay®.

Findings:

  • The VerifyNow P2Y12 Assay® was used to determine on-treatment platelet reactivity in patients experiencing stent thrombosis.
  • This assay helped identify potential causes for the thrombotic events by assessing platelet function.
  • Enhanced platelet reactivity was identified as a potential contributor to stent thrombosis in these cases.

Implications:

  • Point-of-care testing can guide antiplatelet therapy adjustments in patients at high risk for thrombotic events.
  • Identifying poor responders to thienopyridines may help personalize treatment strategies to mitigate residual ischemic risk.
  • These findings highlight the clinical utility of rapid platelet function assays in managing patients undergoing PCI.