Related Experiment Video
Updated: May 27, 2026
03:07
Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
Published on: November 11, 2025
Pancreatic lipomatosis with massive steatorrhea
N A Khan1, M S Amin, M Z Islam
1Department of Radiology & Imaging, Mymensingh Medical College & Hospital, Mymensingh, Bangladesh.
Mymensingh Medical Journal : MMJ
|November 15, 2011
Summary
Pancreatic lipomatosis, a rare cause of exocrine pancreatic failure, can be diagnosed using abdominal CT scans. Treatment with enzyme replacement and cimetidine effectively reduced steatorrhea and improved weight.
Area of Science:
- Gastroenterology
- Radiology
- Pathology
Background:
- Exocrine pancreatic failure is uncommon, with fat replacement of the pancreas being a rare etiology.
- Pancreatic lipomatosis involves the abnormal accumulation of fat within the pancreatic tissue, potentially impairing exocrine function.
Observation:
- A 32-year-old male presented with significant weight loss and massive steatorrhea.
- Abdominal computed tomography (CT) revealed pancreatic lipomatosis, which was subsequently confirmed by fine-needle aspiration cytology (FNAC).
Findings:
- Abdominal CT is a valuable non-invasive tool for diagnosing pancreatic lipomatosis.
- Oral pancreatic enzyme replacement therapy combined with cimetidine resulted in substantial reduction of steatorrhea and promoted weight gain in the patient.
Implications:
- This case highlights the diagnostic utility of CT scans for pancreatic lipomatosis.
- Effective management of pancreatic lipomatosis involves enzyme replacement and acid suppression, leading to improved patient outcomes.
Related Concept Videos
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
01:29Chronic Pancreatitis II: Collaborative Care
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
01:24Lipid Absorption
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...