Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combinatorial Targeting of Avapritinib-Driven MAP Kinase Activation in High-Grade Glioma.

Research square·2026
Same author

Retraction Note: NSD2 targeting reverses plasticity and drug resistance in prostate cancer.

Nature·2026
Same author

pyVIPER: a fast and scalable Python package for protein activity estimation and master regulator analysis of single-cell RNA sequencing data.

BMC bioinformatics·2026
Same author

Targeting of MEK and Autophagy in Pancreatic Adenocarcinoma and Analysis of Treatment Sensitivity in Preclinical and Clinical Models: MEKiAUTO.

JCO precision oncology·2026
Same author

A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer.

The Journal of experimental medicine·2026
Same author

A functional investigation of antibody Fc-FcRn variant binding guided by <i>in silico</i> free energy perturbation methods.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: May 27, 2026

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
08:47

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

Published on: July 5, 2019

Using systems and structure biology tools to dissect cellular phenotypes.

Aris Floratos1, Barry Honig, Dana Pe'er

  • 1Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA.

Journal of the American Medical Informatics Association : JAMIA
|November 15, 2011
PubMed
Summary
This summary is machine-generated.

The MAGNet Center provides structural and systems biology tools for analyzing genetic networks. These tools have led to discoveries in DNA binding and cancer, aiding biomedical research.

More Related Videos

Semi-Automated Phenotypic Analysis of Functional 3D Spheroid Cell Cultures
06:48

Semi-Automated Phenotypic Analysis of Functional 3D Spheroid Cell Cultures

Published on: August 18, 2023

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques
09:48

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques

Published on: June 30, 2017

Related Experiment Videos

Last Updated: May 27, 2026

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
08:47

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

Published on: July 5, 2019

Semi-Automated Phenotypic Analysis of Functional 3D Spheroid Cell Cultures
06:48

Semi-Automated Phenotypic Analysis of Functional 3D Spheroid Cell Cultures

Published on: August 18, 2023

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques
09:48

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques

Published on: June 30, 2017

Area of Science:

  • Structural and Systems Biology
  • Genomics
  • Bioinformatics

Background:

  • The Center for the Multiscale Analysis of Genetic Networks (MAGNet) was founded in 2005.
  • MAGNet aims to equip the biomedical research community with advanced algorithms and software for dissecting molecular interactions and understanding cellular phenotypes.

Purpose of the Study:

  • To develop and provide novel analysis methodologies in structural and systems biology.
  • To facilitate the discovery of genes and biological mechanisms underlying cellular phenotypes, particularly in cancer.

Main Methods:

  • Development of novel computational algorithms for analyzing genetic networks.
  • Creation of integrated software tools, such as geWorkbench, for data analysis.
  • Facilitation of scientific exchange through conferences and meetings.

Main Results:

  • Significant biological discoveries, including the role of DNA shape in protein-DNA binding specificity.
  • Identification of genes causally linked to malignant phenotypes like lymphoma, glioma, and melanoma.
  • Broad adoption of MAGNet's software tools by the research community.

Conclusions:

  • MAGNet has successfully provided valuable tools and methodologies for systems biology and regulatory genomics research.
  • The Center's work has contributed to significant biological insights and advancements in cancer research.
  • Freely available software and organized scientific forums enhance the impact of MAGNet's contributions.