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Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

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Updated: May 27, 2026

Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Cough and Asthma.

¹Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

Current Respiratory Medicine Reviews

|November 15, 2011

Summary

Cough variant asthma (CVA) is a common cause of chronic cough and may progress to classic asthma. Inhaled corticosteroids effectively treat CVA, improving cough and preventing progression by reducing airway remodeling.

Area of Science:

Pulmonology
Allergy and Immunology
Respiratory Medicine

Background:

Cough is a frequent medical complaint, with cough variant asthma (CVA) being a primary cause of chronic cough.
CVA, a distinct asthma presentation, affects 30-40% of adult patients and can evolve into classic asthma if untreated.
CVA shares key features with classic asthma, including atopy, airway hyper-responsiveness, and eosinophilic inflammation.

Purpose of the Study:

To summarize the characteristics and treatment of cough variant asthma.
To highlight the risk of progression from CVA to classic asthma.
To emphasize the role of inhaled corticosteroids in managing CVA.

Main Methods:

Literature review of studies on cough variant asthma.
Analysis of pathophysiological similarities between CVA and classic asthma.

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Evaluation of treatment outcomes for CVA, focusing on inhaled corticosteroids.

Main Results:

Cough variant asthma is a significant cause of chronic cough in adults.
Untreated CVA carries a substantial risk of progressing to classic asthma.
Inhaled corticosteroids demonstrate efficacy in improving CVA symptoms and preventing disease progression.

Conclusions:

Inhaled corticosteroids are the cornerstone treatment for cough variant asthma.
Effective treatment of CVA with inhaled corticosteroids can prevent airway remodeling and chronic airflow obstruction.
Early intervention in CVA is crucial to mitigate the risk of developing classic asthma.