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Vesicular transport systems in fungi
Marcio L Rodrigues1, Joshua D Nosanchuk, Augusto Schrank
1Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Brazil. marcio@micro.ufrj.br
Future Microbiology
|November 16, 2011
Summary
Fungal secretion relies on vesicular transport for moving large molecules across cell walls. These extracellular vesicles play roles in fungal physiology and pathogenesis, impacting host immunity.
Area of Science:
- Mycology
- Cell Biology
- Pathogenesis
Background:
- Eukaryotic secretion mechanisms are known, but fungal secretion across cell walls is less understood.
- Fungal secretion involves trans-cell wall passage of macromolecules, often via vesicles.
- Extracellular fungal vesicles are implicated in virulence and host immune modulation.
Purpose of the Study:
- To review the role of vesicular transport in fungal physiology and pathogenesis.
- To compare fungal secretion mechanisms with those in other organisms.
- To highlight the importance of fungal extracellular vesicles.
Main Methods:
- Literature review and synthesis of recent studies on fungal secretion.
- Comparative analysis of fungal vesicles with mammalian exosomes and vesicles from other kingdoms.
- Discussion of evidence linking vesicular transport to fungal virulence.
Main Results:
- Vesicular transport is essential for fungal trans-cell wall secretion of proteins, lipids, polysaccharides, and pigments.
- Fungal extracellular vesicles can modulate host immunomodulatory activity.
- Fungal vesicles share functional similarities with extracellular vesicles from diverse organisms.
Conclusions:
- Vesicular transport systems are integral to fungal physiology and pathogenesis.
- Understanding fungal extracellular vesicles offers insights into host-pathogen interactions.
- Further research is needed to elucidate the precise cellular origin and functions of fungal vesicles.
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