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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: May 27, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Epigenetic modifications in cancer.

R Kanwal1, S Gupta

  • 1Department of Urology, Case Western Reserve University, Case Comprehensive Cancer Center, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.

Clinical Genetics
|November 16, 2011
PubMed
Summary
This summary is machine-generated.

Epigenetic changes, including DNA methylation and microRNAs, significantly influence cancer development and progression. Understanding these reversible mechanisms is key to discovering new cancer biomarkers.

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Related Experiment Videos

Last Updated: May 27, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

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07:20

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Published on: October 18, 2024

Extraction of Histones from Clinical Specimens for Epigenetic Profiling by Mass Spectrometry
10:54

Extraction of Histones from Clinical Specimens for Epigenetic Profiling by Mass Spectrometry

Published on: November 21, 2025

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer development involves complex genetic and epigenetic alterations.
  • Epigenetics studies heritable gene expression changes without altering DNA sequence.
  • Key epigenetic mechanisms include DNA methylation, histone modifications, and microRNAs (miRNA).

Purpose of the Study:

  • To review the role of epigenetic changes in cancer initiation and progression.
  • To explore how epigenetic alterations contribute to carcinogenesis.
  • To discuss the potential of epigenetics in cancer biomarker discovery.

Main Methods:

  • Literature review of current research on epigenetics and cancer.
  • Analysis of epigenetic mechanisms such as DNA methylation, histone modifications, and miRNA.
  • Synthesis of findings on the link between epigenetic changes and genetic alterations in cancer.

Main Results:

  • Epigenetic disruptions are crucial in early neoplastic development and cancer progression.
  • Aberrant epigenetic modifications lead to altered gene function and malignant transformation.
  • Epigenetic insights enhance understanding of carcinogenesis mechanisms.

Conclusions:

  • Epigenetic factors are essential drivers of cancer initiation and progression.
  • Epigenetic modifications offer promising avenues for cancer early detection and risk assessment.
  • Further research into epigenetics is vital for advancing cancer diagnostics and therapeutics.