Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 27, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Diffusion tensor imaging in episodic cluster headache.

Michael Teepker¹, Katja Menzler, Marcus Belke

¹Department of Neurology, Philipps-University of Marburg, Marburg, Germany.

|November 16, 2011

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reliability of EEG in brain death diagnosis: an analysis of clinical and technical factors.

Frontiers in medicine·2026

Same author

Autoimmune encephalitis-associated epilepsy with glutamic acid decarboxylase autoantibodies and type 1 diabetes mellitus: A comprehensive systematic scoping review of a clinical syndrome.

Autoimmunity reviews·2026

Same author

A translational multimodal machine-learning prototype predicting valproate response in epilepsy treatment.

Epilepsia·2026

Same author

Biofluid-specific variations in circulating 5' transfer RNA fragments during ictal and interictal states in experimental temporal lobe epilepsy.

Epilepsia·2026

Same author

Tumor-associated epilepsy and high expression of xCT shape the proteome of IDH-wildtype glioblastoma.

Cell death discovery·2026

Same author

Current perspectives in sudden unexpected death in epilepsy (SUDEP): epidemiology, research approaches and pathways to prevention.

Neurological research and practice·2026

Same journal

Weight loss with atogepant in the long-term treatment of migraine: An interim analysis of a safety endpoint from a phase 3, multicenter, open-label, 156-week extension study.

Headache·2026

Same journal

American Headache Society 68th Annual Scientific Meeting June 4-7, 2026, Orlando, Florida.

Headache·2026

Same journal

In Memoriam-Doctor J. Keith Campbell.

Headache·2026

Same journal

Hypothalamus as a conductor of the migraine prodrome: A narrative review.

Headache·2026

Same journal

New academic year in Headache.

Headache·2026

Same journal

Essential readings in headache medicine: Top 10 educational articles from 2025.

Headache·2026

See all related articles

This study found microstructural brain changes in patients with cluster headache (CH), suggesting involvement of pain, olfactory, and trigeminal/sympathetic systems. These findings offer new insights into cluster headache pathophysiology.

Area of Science:

Neuroimaging
Neurology
Brain Anatomy

Background:

Cluster headache (CH) is a rare neurological disorder characterized by severe unilateral headaches and autonomic symptoms.
The underlying pathophysiology of CH remains incompletely understood.
Previous studies implicated the hypothalamus and pain matrix in CH episodes, but white matter microstructure data were lacking.

Purpose of the Study:

To investigate white matter microstructure changes in patients with episodic cluster headache during headache-free periods.
To utilize diffusion tensor imaging (DTI) to identify specific brain regions affected by microstructural alterations in CH.

Main Methods:

Diffusion tensor imaging (DTI) was performed on 7 male episodic CH patients and 7 healthy controls using a 1.5 T MRI scanner.

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Related Experiment Videos

Last Updated: May 27, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Fractional anisotropy (FA) values were analyzed across the whole head using track-based spatial statistics.

No a priori hypotheses were applied, allowing for unbiased identification of affected white matter tracts.

Main Results:

Significant bilateral microstructural changes were observed in the white matter of the brainstem, frontal lobe, temporal lobe, occipital lobe, internal capsule, thalamus, and cerebellum.
Lesions were also detected in the basal frontal lobe, potentially involving the olfactory system.
Alterations in FA within the brainstem may suggest changes in the medial lemniscus and central sympathetic pathways.

Conclusions:

Episodic cluster headache patients exhibit microstructural brain alterations within regions associated with the pain matrix.
The study identified structural changes indicating potential involvement of the olfactory system.
Detected lesions in the brainstem suggest a role for trigeminal and sympathetic systems in cluster headache pathophysiology.