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Updated: Feb 14, 2026

Diffusion Imaging in the Rat Cervical Spinal Cord
Published on: April 7, 2015
Management of adjacent segment disease after cervical spinal fusion
Christopher K Kepler1, Alan S Hilibrand
1Department of Orthopaedic Surgery, Thomas Jefferson University & Rothman Institute, 1015 Walnut Street, Room 801, Philadelphia, PA 19107, USA. chris.kepler@gmail.com
Abstract:
Adjacent segment disease (ASD) was described after long-term follow-up of patients treated with cervical fusion. The term describes new-onset radiculopathy or myelopathy referable to a motion segment adjacent to previous arthrodesis and often attributed to alterations in the biomechanical environment after fusion. Evidence suggests that ASD affects between 2% and 3% of patients per year. Although prevention of ASD was one major impetus behind the development of motion-sparing surgery, the literature does not yet clearly distinguish a difference in the rate of ASD between fusion and disk replacement. Surgical techniques during index surgery may reduce the rate of ASD.
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