Related Experiment Video
Updated: May 27, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
A pitfall of fractional flow reserve associated with the presence of collateral circulation
Satoshi Kurisu1, Naoya Mitsuba, Ken Ishibashi
1Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Japan. skurisu@nifty.com
Abstract:
An 82-year-old man had a severe stenosis in the proximal left anterior descending artery (LAD) and an intermediate stenosis in the distal right coronary artery (RCA). The territory of mid to distal LAD was perfused via an angiographically well-developed collateral circulation from the distal RCA. Fractional flow reserve (FFR) in the distal RCA was 0.84. After successful coronary intervention for the proximal LAD, repeat FFR in the distal RCA was 0.96. In this case, the severity of the stenosis in the donor artery was overestimated by using FFR due to the presence of well-developed collateral circulation.
Related Concept Videos
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Peripheral Artery Disease I: Introduction
Aortic Regurgitation I: Introduction
