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Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...

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Related Experiment Video

Updated: May 27, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Morbidity and mortality in schizophrenia.

Am Lwin1, C Symeon, F Jan

  • 1South Essex Partnership Trust, Family Consultation Clinic, Bedfordshire. drlwin11@yahoo.co.uk

British Journal of Hospital Medicine (London, England : 2005)
|November 16, 2011
PubMed
Summary

Schizophrenia increases illness and death rates due to complex genetic and environmental factors. This review examines the causes of physical illness in schizophrenia and the role of antipsychotic medications.

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Development of a Virtual Reality Assessment of Everyday Living Skills
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Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

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Last Updated: May 27, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

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Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Area of Science:

  • Psychiatry
  • Medical Genetics
  • Pharmacology

Background:

  • Schizophrenia is associated with significantly increased morbidity and mortality.
  • Physical health complications are a major concern for individuals with schizophrenia.
  • The interplay of genetic and environmental factors contributes to physical illness in this population.

Purpose of the Study:

  • To review the multifactorial etiology of morbidity and mortality in schizophrenia.
  • To explore the impact of genetic and environmental factors on physical illness.
  • To consider the role of antipsychotic medications in managing physical health.

Main Methods:

  • Literature review of existing research on schizophrenia, morbidity, and mortality.
  • Analysis of studies investigating genetic and environmental influences.
  • Examination of pharmacological data concerning antipsychotic use and physical health outcomes.

Main Results:

  • Schizophrenia's physical health burden results from a complex interplay of factors.
  • Genetic predispositions and environmental stressors significantly influence physical illness.
  • Antipsychotic medications present both benefits and potential risks regarding physical health.

Conclusions:

  • Addressing the high morbidity and mortality in schizophrenia requires a comprehensive approach.
  • Understanding the multifactorial etiology is crucial for effective intervention.
  • Careful consideration of antipsychotic therapy is necessary to optimize physical health outcomes.