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Updated: May 27, 2026

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

First-trimester screening in triplets.

David A Krantz1, Terrence W Hallahan, Kuanglin He

  • 1NTD Laboratories/PerkinElmer, Melville, NY 11747, USA. david.krantz@perkinelmer.com

American Journal of Obstetrics and Gynecology
|November 16, 2011
PubMed
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Adding nasal bone measurement to nuchal translucency screening significantly improves Down syndrome detection rates in triplet pregnancies. Biochemistry screening requires further investigation for its effectiveness.

Area of Science:

  • Maternal-Fetal Medicine
  • Prenatal Diagnostics
  • Genetics

Background:

  • Triplet pregnancies present unique challenges for accurate Down syndrome screening.
  • Traditional screening methods need validation in multifetal gestations.

Purpose of the Study:

  • To evaluate the performance of Down syndrome screening markers in triplet pregnancies.
  • To assess the utility of nuchal translucency, nasal bone, and biochemistry in this population.

Main Methods:

  • Analysis of nuchal translucency (n=794), nasal bone (n=219), and biochemistry (n=198) data in triplet pregnancies.
  • Application of delta and Gaussian models to assess screening performance.
  • Evaluation of detection rates and false-positive rates at 12 weeks' gestation.

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Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
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Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

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Last Updated: May 27, 2026

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

Main Results:

  • Nuchal translucency (NT) combined with nasal bone measurement showed a 93% detection rate at a 10% false-positive rate.
  • The addition of nasal bone significantly reduced the false-positive rate compared to NT alone.
  • Biochemistry markers (free beta-hCG, PAPP-A) showed high median multiples of the median (2.86 and 3.48).

Conclusions:

  • Nasal bone assessment is a valuable addition to nuchal translucency screening in triplet pregnancies, reducing false positives.
  • Further research is needed to establish the role and effectiveness of biochemical markers in triplet Down syndrome screening.