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Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Related Experiment Video

Updated: May 27, 2026

Methylated DNA Immunoprecipitation

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

[Genomic imprinting and carcinogenesis].

Takahiro Arima¹, Hitoshi Hiura, Hiroaki Okae

¹Dept. of Informative Genetics, Tohoku University Graduate School of Medicine, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|November 16, 2011

Summary

Genomic imprinting, an epigenetic process, influences gene expression. Aberrant imprinting is linked to various disorders and cancer, with recent advances aiding clinical applications in cancer diagnostics and drug development.

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Area of Science:

Epigenetics and Molecular Biology
Genetics and Genomics
Developmental Biology

Context:

Genomic imprinting is a fundamental epigenetic mechanism governing parent-of-origin-specific gene expression.
Dysregulation of genomic imprinting is implicated in numerous human diseases, including developmental disorders and cancers.
Imprinted genes are increasingly recognized for their critical roles in the complex processes of carcinogenesis.

Purpose:

To explore the epigenetic mechanisms underlying genomic imprinting.
To analyze the oncogenetic pathways involving imprinted genes.
To highlight the clinical translation of imprinting research in oncology.

Summary:

Genomic imprinting establishes stable, monoallelic gene expression based on parental origin.
Aberrant imprinting contributes to congenital abnormalities, childhood cancers, behavioral disorders, and adult malignancies.
Recent research elucidates the epigenetic basis of imprinting and its role in cancer development.

Impact:

Advances in understanding imprinting's epigenetic mechanisms are paving the way for novel diagnostic tools.
This knowledge is crucial for developing targeted prevention strategies for imprinting-related disorders.
Clinical applications are emerging in cancer drug development, offering new therapeutic avenues.