Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction01:22

Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction

The radical dimerization of ketones or aldehydes gives vicinal diols through a pinacol coupling reaction. However, the behavior of titanium metals used for the reaction as a source of electrons is unusual. When the reaction is carried out in the presence of titanium, diols can be isolated at low temperatures. Else titanium further reacts with diols, forming alkenes through the McMurry reaction.
Ziegler–Natta Chain-Growth Polymerization: Overview01:17

Ziegler–Natta Chain-Growth Polymerization: Overview

Ziegler–Natta polymerization is another form of addition or chain‐growth polymerization used for synthesizing linear polymers over branched polymers. The catalyst used for polymerization is the Ziegler–Natta catalyst, named after Karl Ziegler and Giulio Natta, who developed it in 1953. This catalyst is an organometallic complex of titanium tetrachloride and triethyl aluminum, with the active form of the catalyst being an alkyl titanium compound. Using the Ziegler–Natta catalyst, high molecular...
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Neutral Dy(II) Bis(amide): Synthesis, Magnetism, and a P<sub>4</sub><sup>2-</sup> Complex.

Inorganic chemistry·2025
Same author

Ultra-Confined Environments May Restrict the Possible Configurations of Supported Metal Complexes.

Inorganic chemistry·2025
Same author

Magnetic Hysteresis in a Dysprosium Bis(amide) Complex.

Journal of the American Chemical Society·2025
Same author

Realization of an Elusive U(III) Imido Complex.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024
Same author

Modeling Complex Ligands for High Oxidation State Catalysis: Titanium Hydroamination with Unsymmetrical Ligands.

ACS catalysis·2024
Same author

A rare isocyanide derived from an unprecedented neutral yttrium(ii) bis(amide) complex.

Chemical science·2023

Related Experiment Video

Updated: May 27, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of &#945;-Imino &#947;-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Single-step synthesis of pyrazoles using titanium catalysis.

Amila A Dissanayake1, Aaron L Odom

  • 1Michigan State University, Department of Chemistry East Lansing, MI 48823, USA.

Chemical Communications (Cambridge, England)
|November 16, 2011
PubMed
Summary

A novel titanium complex efficiently synthesizes substituted pyrazoles. This one-step reaction couples alkynes, isonitriles, and hydrazines, offering a streamlined synthetic route.

Area of Science:

  • Organometallic Chemistry
  • Synthetic Organic Chemistry
  • Heterocyclic Chemistry

Background:

  • Pyrazole derivatives are important scaffolds in medicinal chemistry and materials science.
  • Efficient synthetic methods for pyrazoles are crucial for accessing diverse chemical structures.
  • Catalytic approaches offer advantages in terms of atom economy and reaction efficiency.

Purpose of the Study:

  • To develop a novel catalytic system for the synthesis of substituted pyrazoles.
  • To investigate the utility of a simple titanium complex in a multicomponent coupling reaction.
  • To establish a straightforward and efficient one-step method for pyrazole synthesis.

Main Methods:

  • A titanium complex was synthesized and characterized.
  • The catalytic activity of the titanium complex was evaluated in the coupling of alkynes, isonitriles, and monosubstituted hydrazines.

More Related Videos

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)

Published on: January 17, 2020

Related Experiment Videos

Last Updated: May 27, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of &#945;-Imino &#947;-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)

Published on: January 17, 2020

  • Reaction conditions were optimized to maximize yield and purity of the pyrazole products.

    • Main Results:

    • A simple titanium complex was found to effectively catalyze the target reaction.
    • Substituted pyrazoles were successfully synthesized in a single step from readily available starting materials.
    • The catalytic system demonstrated good functional group tolerance and provided access to diverse pyrazole structures.

    Conclusions:

    • A novel and efficient one-step synthesis of substituted pyrazoles has been developed using a simple titanium catalyst.
    • This method provides a valuable new tool for the construction of pyrazole-containing molecules.
    • The catalytic approach offers a sustainable and practical alternative to existing synthetic strategies.