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Updated: May 27, 2026

Method for the Isolation of Francisella tularensis Outer Membranes
Published on: June 29, 2010
The class A β-lactamase FTU-1 is native to Francisella tularensis
Nuno T Antunes1, Hilary Frase, Marta Toth
1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Abstract:
The class A β-lactamase FTU-1 produces resistance to penicillins and ceftazidime but not to any other β-lactam antibiotics tested. FTU-1 hydrolyzes penicillin antibiotics with catalytic efficiencies of 10(5) to 10(6) M(-1) s(-1) and cephalosporins and carbapenems with catalytic efficiencies of 10(2) to 10(3) M(-1) s(-1), but the monobactam aztreonam and the cephamycin cefoxitin are not substrates for the enzyme. FTU-1 shares 21 to 34% amino acid sequence identity with other class A β-lactamases and harbors two cysteine residues conserved in all class A carbapenemases. FTU-1 is the first weak class A carbapenemase that is native to Francisella tularensis.
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