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Updated: May 27, 2026

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Clusterwise HICLAS: a generic modeling strategy to trace similarities and differences in multiblock binary data
T F Wilderjans1, E Ceulemans, P Kuppens
1Katholieke Universiteit Leuven, Leuven, Belgium. tom.wilderjans@psy.kuleuven.be
Abstract:
In many areas of the behavioral sciences, different groups of objects are measured on the same set of binary variables, resulting in coupled binary object × variable data blocks. Take, as an example, success/failure scores for different samples of testees, with each sample belonging to a different country, regarding a set of test items. When dealing with such data, a key challenge consists of uncovering the differences and similarities between the structural mechanisms that underlie the different blocks. To tackle this challenge for the case of a single data block, one may rely on HICLAS, in which the variables are reduced to a limited set of binary bundles that represent the underlying structural mechanisms, and the objects are given scores for these bundles. In the case of multiple binary data blocks, one may perform HICLAS on each data block separately. However, such an analysis strategy obscures the similarities and, in the case of many data blocks, also the differences between the blocks. To resolve this problem, we proposed the new Clusterwise HICLAS generic modeling strategy. In this strategy, the different data blocks are assumed to form a set of mutually exclusive clusters. For each cluster, different bundles are derived. As such, blocks belonging to the same cluster have the same bundles, whereas blocks of different clusters are modeled with different bundles. Furthermore, we evaluated the performance of Clusterwise HICLAS by means of an extensive simulation study and by applying the strategy to coupled binary data regarding emotion differentiation and regulation.
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