Related Experiment Video
Updated: May 27, 2026
10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Bronchopulmonary foregut malformation.
Yoshihiko Katayama1, Hitoshi Kusagawa, Takuya Komada
1Department of Thoracic Surgery, Matsusaka Chuo General Hospital, 102 Konozomu, Kawaimachi, Matsusaka, 515-0818, Japan. kataccho0209@yahoo.co.jp
General Thoracic and Cardiovascular Surgery
|November 16, 2011
Summary
Bronchopulmonary foregut malformation (BPFM) is a rare congenital anomaly. This case details an extralobar pulmonary sequestration (ELS) connected to the esophagus via a cyst, offering insights into its embryogenesis.
Area of Science:
- Medical Science
- Developmental Biology
- Thoracic Surgery
Background:
- Bronchopulmonary foregut malformation (BPFM) encompasses rare ventral anomalies of accessory pulmonary tissue, often originating from the esophagus or stomach.
- BPFM specifically describes sequestrations retaining gastrointestinal tract communication, typically via a muscular tube lined with squamous or columnar epithelium.
Observation:
- A rare case of extralobar pulmonary sequestration (ELS) in an adult is presented.
- The ELS was found to be connected to the esophagus through a cyst.
- This connecting cyst's inner wall featured both squamous and respiratory epithelium.
Findings:
- The study describes a unique BPFM case involving ELS connected to the esophagus by a foregut cyst.
- The cyst's dual epithelial lining (squamous and respiratory) suggests a specific embryogenic origin.
- This finding provides a detailed example of BPFM with a distinct anatomical connection.
Implications:
- Understanding the embryogenesis of BPFM is crucial for accurate diagnosis and surgical planning.
- This case highlights the importance of detailed histological examination of the connecting stalk in BPFM.
- Further research into these rare malformations can improve patient outcomes and diagnostic criteria.
Related Concept Videos
01:11Pyloric Obstruction
Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:17Pulmonary Cycle: Exhalation
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
01:30Respiratory System Abnormal Finding I: Inspection and Percussion
Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
01:31Respiratory System Abnormal Finding II: Palpation and Auscultation
In assessing respiratory abnormalities, palpation and auscultation are critical tools for detecting and interpreting various pathophysiological changes. These techniques provide insight into underlying disorders by evaluating tactile sensations and sounds produced by the respiratory system.
Palpation Findings
During a respiratory assessment, palpation can reveal several vital abnormalities:
Palpation Findings
During a respiratory assessment, palpation can reveal several vital abnormalities:
01:22Esophageal Perforation-I: Introduction
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.