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Updated: May 27, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107
Francesca Vasile1, Donatella Potenza, Barbara Marsiglia
1Organic and Industrial Chemistry Department, University of Milano, Milan, Italy. francesca.vasile@unimi.it
Abstract:
Lantibiotics 97518 and NAI-107, produced by the related genera Planomonospora and Microbispora respectively, are members of a family of nisin-related compounds. They represent promising compounds to treat infections caused by multiresistant Gram-positive pathogens. Despite their similar structure and a similar antibacterial spectrum, the two lantibiotics exhibit significant differences in their potency. To gain an insight into the structure-activity relationships, their conformational properties in solution are determined by NMR. After carrying out an NOE analysis of 2D (1)H NMR spectra, high-resolution 3D structures are determined using molecular dynamics simulations.
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