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Synthesis of a new chemically stable prostacyclin analogue with high and long-lasting activity
K Iseki1, T Kanayama, Y Hayasi
1Research Center, Mitsubishi Kasei Corporation, Yokohama, Japan.
Chemical & Pharmaceutical Bulletin
|June 1, 1990
Abstract:
The chemically stable prostacyclin analogue (Z)-4,5-didehydroisocarbacyclin analogue (6) has been synthesized. Compound 6 given intravenously or orally is very potent in inhibiting platelet aggregation.