Related Experiment Video
Updated: May 27, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Royal jelly reduces melanin synthesis through down-regulation of tyrosinase expression
Sang Mi Han1, Joo Hong Yeo, Yoon Hee Cho
1Laboratory of Applied Material Science, Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA, Suwon, South Korea.
Abstract:
For cosmetic reasons, the demand for effective and safe skin-whitening agents is high. Since the key enzyme in the melanin synthetic pathway is tyrosinase, many depigmenting agents in the treatment of hyperpigmentation act as tyrosinase inhibitors. In this study, we have investigated the hypo-pigmentary mechanism of royal jelly in a mouse melanocyte cell line, B16F1. Treatment of B16F1 cells with royal jelly markedly inhibited melanin biosynthesis in a dose-dependent manner. Decreased melanin content occurred through the decrease of tyrosinase activity. The mRNA levels of tyrosinase were also reduced by royal jelly. These results suggest that royal jelly reduces melanin synthesis by down-regulation of tyrosinase mRNA transcription and serves as a new candidate in the design of new skin-whitening or therapeutic agents.
Related Concept Videos
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
Epistasis
Epistasis Analysis
MicroRNAs
MicroRNAs
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
