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Whipple limbic encephalitis.

Frédéric Blanc¹, Kaouther Ben Abdelghani, Frédéric Schramm

¹Neuropsychology Service and CMRR-Memory Resource and Research Centre, Department of Neurology, University Hospital of Strasbourg, Strasbourg, France.

Archives of Neurology

|November 16, 2011

Summary

This summary is machine-generated.

Whipple disease can relapse presenting solely as limbic encephalitis, a rare neurological manifestation. Early diagnosis and treatment are crucial for managing this rare condition.

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Area of Science:

Neurology
Infectious Diseases

Background:

Whipple disease is a rare systemic infectious disease caused by Tropheryma whipplei.
Neurological involvement in Whipple disease is well-documented but often presents with diverse symptoms.

Observation:

A 41-year-old patient with a history of inadequately treated Whipple disease presented with isolated limbic encephalitis.
Symptoms included headache, anterograde amnesia, and temporospatial disorientation without other systemic signs.

Findings:

Neuropsychological evaluation revealed impaired episodic memory and executive functions.
Cerebrospinal fluid analysis showed lymphocytosis and positive Tropheryma whipplei PCR.
Brain MRI demonstrated characteristic limbic encephalitis with hippocampal and amygdala involvement.

Implications:

This case highlights that Whipple disease relapse can manifest as isolated limbic encephalitis.
Prompt diagnosis and specific antibiotic treatment are essential for improving cognitive outcomes and reducing inflammation.
Further research into rare neurological presentations of Whipple disease is warranted.