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Updated: May 27, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p73-Binding Partners and Their Functional Significance.
Toshinori Ozaki1, Natsumi Kubo, Akira Nakagawara
1Laboratory of Anti-tumor Research, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.
International Journal of Proteomics
|November 16, 2011
Summary
The tumor suppressor p73, a p53 family member, regulates cell death and cycle arrest following DNA damage. Its function is primarily controlled by protein-protein interactions and posttranslational modifications.
Area of Science:
- Molecular Biology
- Cancer Research
- Cell Biology
Background:
- p73 is a tumor suppressor in the p53 family, structurally similar to p53.
- Despite its tumor-suppressive role, p73 mutations are rare in human tumors.
- p73 levels are low under normal conditions but increase upon DNA damage.
Purpose of the Study:
- To investigate the functional significance of protein-protein interactions in regulating the proapoptotic function of p73.
- To understand how p73's tumor-suppressive activity is modulated.
Main Methods:
- The study focuses on analyzing protein-protein interactions.
- Posttranslational modifications like phosphorylation and acetylation are examined in relation to these interactions.
Main Results:
- p73 is induced by specific DNA damages, activating p53-target genes.
- This activation leads to cell cycle arrest and/or apoptosis, dependent on the DNA damage.
- Protein-protein interactions are crucial for regulating p73's posttranslational modifications and activity.
Conclusions:
- Protein-protein interactions are key regulators of p73's tumor-suppressive and proapoptotic functions.
- Understanding these interactions provides insight into p73's role in DNA damage response and cancer.
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