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Updated: May 27, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Modular synthesis of functionalized bis-bispidine tetraazamacrocycles
Zhuo Wang1, Erin J Miller, Samantha J Scalia
1Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada N9B 3P4. zhuowang@uwindsor.ca
Abstract:
An effective synthesis is reported for the construction of highly rigid and preorganized bis-bispidine tetraazamacrocycles bearing either identical or different functionalities. Using essential building blocks derived from N-Boc-N'-allylbispidinone, the modular approach facilitates independent incorporation of the functional groups to the macrocyclic framework as well as selective derivatization of one functionality in the presence of another.
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