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Genetic polymorphisms of UGT1A7 and cancer risk: evidence from 21 case-control studies
Pei-Hua Lu1, Min-Bin Chen, Xiao-Yang Wu
1Department of Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Jiangsu Province, China.
Abstract:
The aim of our meta-analysis was to assess the association between UGT1A7 polymorphisms and cancer risk. Case?control studies containing available polymorphic alleles (UGT1A7*1,*2,*3, and*4) and genotypes categorized according to enzymatic activity (High, Intermediate, and Low) were chosen to assess this association. Twenty-one case?control studies were identified. Meta-analysis indicated that UGT1A7 had a significant effect on cancer risk. In subgroup analysis, a significantly increased risk was associated with East Asians, hepatocellular cancer, and colorectal cancer. This meta-analysis suggested that there is a cancer risk associated with UGT1A7*3, Intermediate, and Low activity UGT1A7 genotypes, which is most evident in Asian individuals.
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